Rejected results: Addressing transparency in clinical trials
نویسندگان
چکیده
منابع مشابه
Transparency for clinical trials--the TEST Act.
In the past few years, registration of clinical trials in a publicly accessible database has become routine. In the United States, much of the impetus for registration derives from the Food and Drug Administration Amendments Act of 2007 (FDAAA). As a result of this law and other actions,1,2 most interventional clinical trials conducted in the United States have been registered at ClinicalTrials...
متن کاملProspective registration and results disclosure of clinical trials in the Americas: a roadmap toward transparency.
The objective of this article is to propose a roadmap toward transparency of clinical trials in the Americas by their prospective registration and results disclosure. This will broaden access to more complete and accurate data and facilitate evidence-informed decision-making and participation in research. Consequently, it should have a positive impact on people's health and should promote trust...
متن کاملBlockchain protocols in clinical trials: Transparency and traceability of consent
Clinical trial consent for protocols and their revisions should be transparent for patients and traceable for stakeholders. Our goal is to implement a process allowing the collection of patients' informed consent, which is bound to protocol revisions, storing and tracking the consent in a secure, unfalsifiable and publicly verifiable way, and enabling the sharing of this information in real tim...
متن کاملLack of transparency in clinical trials: a call for action
Th e purpose of pharmacological and non-pharmacological medical interventions are maintenance of good health, delay pathology and rehabilitate patients with disability. Because any intervention have the risk of adverse effects, physicians have to weigh benefits against harms before deciding the best treatment for the patient condition, a practice of rational prescription supported by high-quali...
متن کاملImproving data transparency in clinical trials using blockchain smart contracts
The scientific credibility of findings from clinical trials can be undermined by a range of problems including missing data, endpoint switching, data dredging, and selective publication. Together, these issues have contributed to systematically distorted perceptions regarding the benefits and risks of treatments. While these issues have been well documented and widely discussed within the profe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Bulletin of the Royal College of Surgeons of England
سال: 2015
ISSN: 1473-6357,1478-7075
DOI: 10.1308/rcsbull.2015.97.5.204